Development of collagen-hydroxyapatite scaffolds incorporating PLGA and alginate microparticles for the controlled delivery of rhBMP-2 for bone tissue engineering.

@article{Quinlan2015DevelopmentOC,
  title={Development of collagen-hydroxyapatite scaffolds incorporating PLGA and alginate microparticles for the controlled delivery of rhBMP-2 for bone tissue engineering.},
  author={Elaine Quinlan and Adolfo L{\'o}pez-Noriega and Emmet M Thompson and Helena M. Kelly and Sally Ann Cryan and Fergal J O'Brien},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2015},
  volume={198},
  pages={71-9}
}
The spatiotemporally controlled delivery of the pro-osteogenic factor rhBMP-2 would overcome most of the severe secondary effects linked to the products delivering this protein for bone regeneration. With this in mind, the aim of the present work was to develop a controlled rhBMP-2 release system using collagen-hydroxyapatite (CHA) scaffolds, which had been… CONTINUE READING