Development of chronic tests for endocrine active chemicals. Part 2: an extended fish early-life stage test with an androgenic chemical in the fathead minnow (Pimephales promelas).

@article{Bogers2006DevelopmentOC,
  title={Development of chronic tests for endocrine active chemicals. Part 2: an extended fish early-life stage test with an androgenic chemical in the fathead minnow (Pimephales promelas).},
  author={Rinus Bogers and Selinda de Vries-Buitenweg and M E van Gils and Erik Baltussen and Adam Hargreaves and Beppy J Van de Waart and Daphne F de Roode and Juliette Legler and Albertinka Jacoba Murk},
  journal={Aquatic toxicology},
  year={2006},
  volume={80 2},
  pages={
          119-30
        }
}
The Endocrine Modulators Study Group (EMSG) of the European Chemical Industry has proposed an extended fish early-life stage (ELS) test based on OECD test guideline 210 in combination with a fish pair-breeding reproduction study as a possible alternative for fish full life cycle testing. In this paper the androgen methyldihydrotestosterone (MDHT) was tested in an extended ELS test with fathead minnow supplementary to such a test with the weak estrogen 4-tert-pentylphenol (4TPP). Main endpoints… CONTINUE READING

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