Development of cellulose derivatives as novel enteric coating agents soluble at pH 3.5-4.5 and higher.

@article{Kokubo1997DevelopmentOC,
  title={Development of cellulose derivatives as novel enteric coating agents soluble at pH 3.5-4.5 and higher.},
  author={Hiroyasu Kokubo and Saka{\'e} Obara and Kesami Minemura and Toshiki Tanaka},
  journal={Chemical & pharmaceutical bulletin},
  year={1997},
  volume={45 8},
  pages={1350-3}
}
Hydroxypropyl methylcellulose (HPMC) was selected as a base polymer to develop novel enteric coating agents for acid protection which can dissolve at pH around 4, and was modified with trimellitic acid or maleic acid at various degrees of substitution. These carboxylic acids have higher dissociation constants and higher solubility in water than the carboxylic acids of existing enteric coating polymers. The synthesized polymers were micronized and dispersed in aqueous medium to determine their… CONTINUE READING