Development of cell-penetrating peptide-modified MPEG-PCL diblock copolymeric nanoparticles for systemic gene delivery.

@article{Tanaka2010DevelopmentOC,
  title={Development of cell-penetrating peptide-modified MPEG-PCL diblock copolymeric nanoparticles for systemic gene delivery.},
  author={Ko Tanaka and Takanori Kanazawa and Yasunori Shibata and Yumiko Suda and Tsunehiko Fukuda and Yuuki Takashima and Hiroaki Okada},
  journal={International journal of pharmaceutics},
  year={2010},
  volume={396 1-2},
  pages={229-38}
}
To develop a safe and efficient systemic non-viral gene vector, methoxy poly(ethylene glycol) (MPEG)/poly(epsilon-caprolactone) (PCL) diblock copolymers conjugated with a Tat analog through the ester or disulfide linkage were synthesized and their suitability as a systemic non-viral gene carrier evaluated. The physicochemical properties of the MPEG-PCL diblock copolymers were determined by GPC, (1)H NMR and FT-IR spectroscopy. The particle sizes and in vitro (COS7 and S-180 cells) transfection… CONTINUE READING

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