Development of catheter-based procedures for transducing the isolated rabbit liver with plasmid DNA.

@article{Eastman2002DevelopmentOC,
  title={Development of catheter-based procedures for transducing the isolated rabbit liver with plasmid DNA.},
  author={Simon J Eastman and Kevin M. Baskin and Bradley L. Hodges and Qiuming Chu and Amy Gates and Rebecca Dreusicke and Scott T Anderson and Ronald K. Scheule},
  journal={Human gene therapy},
  year={2002},
  volume={13 17},
  pages={2065-77}
}
Rapid systemic injection of naked plasmid DNA (pDNA) in a large volume into a mouse tail vein has been shown to result in a high level of gene expression in the liver. However, the potential therapeutic benefit to humans embodied in hydrodynamic transfection of the liver cannot be realized until a clinically viable method for gene delivery is developed. In light of this fact, we have devised and evaluated several methods for delivering pDNA to the isolated rabbit liver using minimally invasive… CONTINUE READING
52 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 52 extracted citations

Similar Papers

Loading similar papers…