Development of cardiac hypertrophy by sunitinib in vivo and in vitro rat cardiomyocytes is influenced by the aryl hydrocarbon receptor signaling pathway

@article{Maayah2013DevelopmentOC,
  title={Development of cardiac hypertrophy by sunitinib in vivo and in vitro rat cardiomyocytes is influenced by the aryl hydrocarbon receptor signaling pathway},
  author={Zaid H. Maayah and Mushtaq Ahmad Ansari and Mohamed A. El Gendy and Mohammed N. Al-Arifi and Hesham M. Korashy},
  journal={Archives of Toxicology},
  year={2013},
  volume={88},
  pages={725-738}
}
Sunitinib (SUN) is a new tyrosine kinase inhibitor that possesses both anti-angiogenic and anti-tumor activities. Although SUN has improved survival rate in cancer patients, cardiotoxicity has been reported as a significant side effect. Several studies suggested a role for the aryl hydrocarbon receptor (AhR) and its regulated genes such as cytochrome P4501A1 (CYP1A1) in the pathogenesis of heart failure and cardiac hypertrophy. To test the hypothesis that SUN induces cardiac hypertrophy through… CONTINUE READING

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