Development of brucine-loaded microsphere/thermally responsive hydrogel combination system for intra-articular administration.


Intra-articular drug delivery system could directly deliver a drug to an affected joint and offer the possibility of reaching high drug concentrations at the site of action with limited systemic toxicity. However, depending on their chemical structure, some active compounds were rapidly cleared from the joint, thus requiring numerous injections, which could… (More)
DOI: 10.1016/j.jconrel.2012.07.037


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