Development of broad‐spectrum human monoclonal antibodies for rabies post‐exposure prophylaxis

@inproceedings{Benedictis2016DevelopmentOB,
  title={Development of broad‐spectrum human monoclonal antibodies for rabies post‐exposure prophylaxis},
  author={Paola De Benedictis and Andrea Minola and Elena Rota Nodari and Roberta Aiello and Barbara Zecchin and Angela Salomoni and Mathilde Foglierini and Gloria Agatic and Fabrizia Vanzetta and Rachel Lavenir and Anthony Lepelletier and Emma M Bentley and Robin A Weiss and Giovanni Cattoli and Ilaria 3 Capua and Federica Sallusto and Edward M. Wright and Antonio Lanzavecchia and Herv{\'e} Bourhy and Davide Corti},
  booktitle={EMBO molecular medicine},
  year={2016}
}
Currently available rabies post-exposure prophylaxis (PEP) for use in humans includes equine or human rabies immunoglobulins (RIG). The replacement of RIG with an equally or more potent and safer product is strongly encouraged due to the high costs and limited availability of existing RIG. In this study, we identified two broadly neutralizing human monoclonal antibodies that represent a valid and affordable alternative to RIG in rabies PEP. Memory B cells from four selected vaccinated donors… CONTINUE READING

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