Development of botulinum toxin therapy.

  title={Development of botulinum toxin therapy.},
  author={Alan B. Scott},
  journal={Dermatologic clinics},
  volume={22 2},
          131-3, v
Justinius Kerner collected data on 230 cases of botulism in the 1820s, suggested the therapeutic use of toxin, and gave a remarkably complete and accurate description of clinical botulism: its symptoms, time course, and the physical findings that the tear fluid disappears, the skin is dry, the eye, gut, and somatic muscles are paralyzed, and mucus and saliva secretion is suppressed. These effects are the clinical targets of botulinum therapy today. Inspired by Drachman's use of toxin to safely… CONTINUE READING