• Corpus ID: 19063545

Development of beta-lactamase inhibitors.

@article{Sutherland1990DevelopmentOB,
  title={Development of beta-lactamase inhibitors.},
  author={Robert Sutherland},
  journal={The Journal of reproductive medicine},
  year={1990},
  volume={35 3 Suppl},
  pages={
          307-12
        }
}
  • R. Sutherland
  • Published 1 March 1990
  • Biology, Medicine
  • The Journal of reproductive medicine
The resistance of bacteria to beta-lactam antibiotics was first associated with the production of the enzyme beta-lactamase as long ago as 1940. Since then, increasing numbers of beta-lactamase-producing bacteria capable of inactivating penicillins and cephalosporins have been isolated clinically. One approach to the problem posed by beta-lactamase-producing bacteria has been to seek substances that function as inhibitors of beta-lactamase and that can be used to protect beta-lactam antibiotics… 
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Beta-lactamase inhibitor was purified and characterized as clavulanic acid by using nuclear magnetic resonance (NMR) spectroscopy analysis, infra-red (IR) spectrapopy analysis and elemental analysis, and eventually, amoxicillin-resistant P. aeruginosa was inhibited by am toxicillin-clavULanic acid combination at 125 µg ml -1 and 128 mg ml - 1 , respectively.
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  • R. Weber
  • Medicine, Biology
    Ear, nose, & throat journal
  • 1997
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Results suggest that the beta-lactam/beta- lactamase-inhibitor combination ampi-cillin/sulbactam is cost-effective for perioperative treatment of patients undergoing head and neck surgery.