Development of autoimmune exocrinopathy resembling Sjögren's syndrome in estrogen-deficient mice of healthy background.

  title={Development of autoimmune exocrinopathy resembling Sj{\"o}gren's syndrome in estrogen-deficient mice of healthy background.},
  author={Naozumi Ishimaru and Rieko Arakaki and Megumi Watanabe and Masaru Kobayashi and Katsushi Miyazaki and Yoshio Hayashi},
  journal={The American journal of pathology},
  volume={163 4},
Although a number of autoimmune diseases are known to develop in postmenopausal women, the mechanisms by which estrogen deficiency influences autoimmune lesions remain unclear. We speculate that antiestrogenic actions might be a potent factor in the formation of pathogenic autoantigens. Previously, we have identified 120-kd alpha-fodrin as an important autoantigen in Sjögren's syndrome (SS). When healthy C57BL/6 (B6) mice were treated with an ovariectomy (Ovx), we found a significant increase… CONTINUE READING


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