Development of autoantibodies before the clinical onset of systemic lupus erythematosus.

@article{Arbuckle2003DevelopmentOA,
  title={Development of autoantibodies before the clinical onset of systemic lupus erythematosus.},
  author={Melissa R Arbuckle and Micah T. McClain and Mark V. Rubertone and Robert Hal Scofield and Gregory J Dennis and Judith A James and John Barker Harley},
  journal={The New England journal of medicine},
  year={2003},
  volume={349 16},
  pages={1526-33}
}
BACKGROUND Although much is known about the natural history of systemic lupus erythematosus (SLE), the development of SLE autoantibodies before the diagnosis of the disease has not been extensively explored. We investigated the onset and progression of autoantibody development before the clinical diagnosis. METHODS The Department of Defense Serum Repository contains approximately 30 million specimens prospectively collected from more than 5 million U.S. Armed Forces personnel. We evaluated… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS