Development of anti-human B blood group monoclonal antibodies suitable as a blood typing reagent.

@article{Becker1994DevelopmentOA,
  title={Development of anti-human B blood group monoclonal antibodies suitable as a blood typing reagent.},
  author={Mar{\'i}a In{\'e}s Becker and F Juica and Adolfo Jamett and S. Tzichinovsky and Samuel de Barros and Juan Andr{\'e}s Lizama Aguayo and Alfredo E. De Ioannes},
  journal={Hybridoma},
  year={1994},
  volume={13 4},
  pages={
          303-10
        }
}
An improved procedure for the generation of high-avidity anti-human B blood group monoclonal antibodies (MAbs) was developed. One of them, termed 7A1-2, showed excellent qualities of titer, avidity, and intensity required for use as human B blood typing reagent. Hemagglutination inhibition studies with monosaccharides and oligosaccharides were carried out to determine the specificity of the MAb 7A1-2. These studies indicate that the antibody reacts with the immunodominant region of the antigen… CONTINUE READING
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