Development of anti-atherosclerotic tissue-engineered blood vessel by A20-regulated endothelial progenitor cells seeding decellularized vascular matrix.

@article{Zhu2008DevelopmentOA,
  title={Development of anti-atherosclerotic tissue-engineered blood vessel by A20-regulated endothelial progenitor cells seeding decellularized vascular matrix.},
  author={Chuhong Zhu and Dajun Ying and Jianhong Mi and Li Li and Wen Zeng and Chunli Hou and Jiansen Sun and Wei Yuan and Can Wen and Wei Zhang},
  journal={Biomaterials},
  year={2008},
  volume={29 17},
  pages={2628-36}
}
To investigate whether decellularized vascular tissues and A20-regulated endothelial progenitor cells can be used for constructing a transgenic tissue-engineered blood vessel with anti-atherosclerotic vascular stenotic properties. A20 gene-transfected endothelial progenitor cells differentiated endothelial cells and smooth muscle cells attached to and migrated into the decellularized porcine vascular scaffolding in a bioreactor. The histology of the conduits revealed viable and layered tissue… CONTINUE READING