Development of animal models for adeno-associated virus site-specific integration.

@article{Rizzuto1999DevelopmentOA,
  title={Development of animal models for adeno-associated virus site-specific integration.},
  author={Gabrielle Rizzuto and B Gorgoni and Marco Cappelletti and Domenico Lazzaro and Isabelle Gloaguen and V. Poli and Antonella Sgura and Donatella Cimini and G. Ciliberto and Riccardo Cortese and Elena Fattori and Nicola La Monica},
  journal={Journal of virology},
  year={1999},
  volume={73 3},
  pages={2517-26}
}
The adeno-associated virus (AAV) is unique in its ability to target viral DNA integration to a defined region of human chromosome 19 (AAVS1). Since AAVS1 sequences are not conserved in a rodent's genome, no animal model is currently available to study AAV-mediated site-specific integration. We describe here the generation of transgenic rats and mice that carry the AAVS1 3.5-kb DNA fragment. To test the response of the transgenic animals to Rep-mediated targeting, primary cultures of mouse… CONTINUE READING

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