Development of an ultra high sensitive tissue biosensor for determination of swellfish poisoning, tetrodotoxin.

@article{Cheun1996DevelopmentOA,
  title={Development of an ultra high sensitive tissue biosensor for determination of swellfish poisoning, tetrodotoxin.},
  author={B S Cheun and Hideaki Endo and Tetsuhito Hayashi and Yuji Nagashima and Etsuo Watanabe},
  journal={Biosensors & bioelectronics},
  year={1996},
  volume={11 12},
  pages={1185-91}
}
A simple tissue biosensor for measuring Na+ channel blockers such as tetrodotoxin (TTX) and saxitoxin (STX) has been developed. The membrane of frog bladder has Na+ channels which control the passage of Na+. It is well known that TTX blocks Na+ channels. The tissue biosensor consists of a Na+ electrode integrated within a flow cell. The tip of the electrode was covered with frog bladder membrane sandwiched between two sheets of cellulose acetate membrane, and the electrode was set in a flow… CONTINUE READING