Development of an ultra-fast liquid chromatography-tandem mass spectrometry method for simultaneous determination of seven flavonoids in rat plasma: Application to a comparative pharmacokinetic investigation of Ginkgo biloba extract and single pure ginkgo flavonoids after oral administration.

Abstract

For deeper pharmacokinetic investigation and further curative application of ginkgo flavonoids, a delicate, efficient and precise UFLC-MS/MS technique for synchronous quantitation of seven flavonoids, apigenin, luteolin, naringenin, quercetin, diosmetin, kaempferol and isorhamnetin in rat plasma has been established. After mixing with the internal standard… (More)
DOI: 10.1016/j.jchromb.2017.05.021

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Cite this paper

@article{Wang2017DevelopmentOA, title={Development of an ultra-fast liquid chromatography-tandem mass spectrometry method for simultaneous determination of seven flavonoids in rat plasma: Application to a comparative pharmacokinetic investigation of Ginkgo biloba extract and single pure ginkgo flavonoids after oral administration.}, author={Tianyang Wang and Jie Xiao and Huiping Hou and Pei Li and Ziyue Yuan and Huarong Xu and Ran Liu and Qing Li and Kaishun Bi}, journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences}, year={2017}, volume={1060}, pages={173-181} }