Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases.

Abstract

Quantification studies of complex protein mixtures have been restricted mainly to whole cell extracts. Here we describe the synthesis of two sets of isotope-coded activity-based probes that allow quantitative functional proteomics experiments on the cathepsins.

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Cite this paper

@article{Swieten2004DevelopmentOA, title={Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases.}, author={Paul F van Swieten and Ren{\'e} Maehr and Adrianus M C H van den Nieuwendijk and Benedikt M. Kessler and Michael Reich and C Wong and Hubert Kalbacher and Michiel A Leeuwenburgh and Christoph Driessen and Gijsbert A. van der Marel and Hidde L. Ploegh and Herman S Overkleeft}, journal={Bioorganic & medicinal chemistry letters}, year={2004}, volume={14 12}, pages={3131-4} }