Development of an intranasal vaccine to prevent urinary tract infection by Proteus mirabilis.

@article{Li2004DevelopmentOA,
  title={Development of an intranasal vaccine to prevent urinary tract infection by Proteus mirabilis.},
  author={Xin Li and C. Virginia Lockatell and David E. Johnson and M. Chelsea Lane and John W. Warren and Harry L. T. Mobley},
  journal={Infection and immunity},
  year={2004},
  volume={72 1},
  pages={66-75}
}
Proteus mirabilis commonly infects the complicated urinary tract and is associated with urolithiasis. Stone formation is caused by bacterial urease, which hydrolyzes urea to ammonia, causing local pH to rise, and leads to the subsequent precipitation of magnesium ammonium phosphate (struvite) and calcium phosphate (apatite) crystals. To prevent these infections, we vaccinated CBA mice with formalin-killed bacteria or purified mannose-resistant, Proteus-like (MR/P) fimbriae, a surface antigen… CONTINUE READING

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