Development of an inhaled dry-powder formulation of tobramycin using PulmoSphere™ technology.

  title={Development of an inhaled dry-powder formulation of tobramycin using PulmoSphere™ technology.},
  author={David E. Geller and Jeffry Weers and Silvia Heuerding},
  journal={Journal of aerosol medicine and pulmonary drug delivery},
  volume={24 4},
Abstract At present, the only approved inhaled antipseudomonal antibiotics for chronic pulmonary infections in patients with cystic fibrosis (CF) are nebulized solutions. However, prolonged administration and cleaning times, high administration frequency, and cumbersome delivery technologies with nebulizers add to the high treatment burden in this patient population. PulmoSphere™ technology is an emulsion-based spray-drying process that enables the production of light porous particle, dry… CONTINUE READING
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