Development of an in vivo 19F magnetic resonance method for measuring oxygen deficiency in tumors.

@article{Raleigh1991DevelopmentOA,
  title={Development of an in vivo 19F magnetic resonance method for measuring oxygen deficiency in tumors.},
  author={James Raleigh and Allan J. Franko and Deirdre A. Kelly and Laird A. Trimble and Peter S. Allen},
  journal={Magnetic resonance in medicine},
  year={1991},
  volume={22 2},
  pages={
          451-66
        }
}
A 19F magnetic resonance spectroscopy (MRS) approach to measuring hypoxia in experimental tumors in rats at a field strength of 2.35 T has been investigated in a combined study of in situ and excised tumors. The detection of tumor hypoxia is based on the hypoxia marker approach which depends on the selective, covalent binding of a fluorinated 2-nitroimidazole to hypoxic cells. The 19F MRS measurement of in vivo hypoxia marker binding was made at a fixed postinjection time when unbound… CONTINUE READING

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