Development of an in vitro screening model for the biosynthesis of acyl glucuronide metabolites and the assessment of their reactivity toward human serum albumin.

@article{Bolze2002DevelopmentOA,
  title={Development of an in vitro screening model for the biosynthesis of acyl glucuronide metabolites and the assessment of their reactivity toward human serum albumin.},
  author={S{\'e}bastien Bolze and Norbert Bromet and Croisine Gay-Feutry and Fr{\'e}d{\'e}ric Massiere and Roselyne Boulieu and Thierry Hulot},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2002},
  volume={30 4},
  pages={
          404-13
        }
}
An in vitro screening model was developed to determine the reactivity of acyl glucuronide metabolites from carboxylic drugs. This assay is composed of two phases. The first is a phase of biosynthesis of acyl glucuronides by human liver microsomes (HLM). The second, during which acyl glucuronides are incubated with human serum albumin (HSA), consists of assessing the reactivity of acyl glucuronides toward HSA. Both phases are performed successively in the same experiment. This model was… CONTINUE READING

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