Development of an in vitro photosensitization assay using human monocyte-derived cells.

@article{Hoya2009DevelopmentOA,
  title={Development of an in vitro photosensitization assay using human monocyte-derived cells.},
  author={M. Hoya and M. Hirota and M. Suzuki and S. Hagino and H. Itagaki and S. Aiba},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2009},
  volume={23 5},
  pages={
          911-8
        }
}
  • M. Hoya, M. Hirota, +3 authors S. Aiba
  • Published 2009
  • Biology, Medicine
  • Toxicology in vitro : an international journal published in association with BIBRA
In this study, with the aim of developing a cell-based in vitro photosensitization assay, we examined whether changes of CD86 and CD54 expression on cells of a human monocytic cell line, THP-1, could be used to assess the photosensitizing potential of chemicals. First, we identified suitable conditions of UV-irradiation (irradiation dose; 5.0 J/cm(2), irradiation intensity; 1.7 mW/cm(2)) by investigating the effect of UV-irradiation on CD86 and CD54 expression on untreated or 6-methylcoumarin… Expand
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References

SHOWING 1-10 OF 36 REFERENCES
Evaluation of the skin sensitization potential of chemicals using expression of co-stimulatory molecules, CD54 and CD86, on the naive THP-1 cell line.
  • 119
UVA-induced immune suppression through an oxidative pathway.
  • 83
Development of an in vitro skin sensitization test using human cell lines: the human Cell Line Activation Test (h-CLAT). I. Optimization of the h-CLAT protocol.
  • T. Ashikaga, Y. Yoshida, +7 authors H. Toyoda
  • Medicine, Chemistry
  • Toxicology in vitro : an international journal published in association with BIBRA
  • 2006
  • 278
Induction of keratinocyte apoptosis by photosensitizing chemicals plus UVA.
  • 25
Differential modulation of human epidermal Langerhans cell maturation by ultraviolet B radiation.
  • 56
  • PDF
In vivo UVA-1 and UVB irradiation differentially perturbs the antigen-presenting function of human epidermal Langerhans cells.
  • 24
Further Characterization of UVB Radiation Effects on Langerhans Cells: Altered Expression of the Costimulatory Molecules B7‐1 and B7‐2
  • 23
...
1
2
3
4
...