Development of an in vitro model to study the impact of BMP-2 on metastasis to bone.

@article{Kwon2010DevelopmentOA,
  title={Development of an in vitro model to study the impact of BMP-2 on metastasis to bone.},
  author={Heenam Kwon and Hyeon Joo Kim and William Rice and Balajikarthick Subramanian and Sang-Hyug Park and Irene Georgakoudi and David L Kaplan},
  journal={Journal of tissue engineering and regenerative medicine},
  year={2010},
  volume={4 8},
  pages={590-9}
}
Prostate cancer cases and deaths have increased for years, yet the mechanisms involved in prostate cancer metastasis to bone remain poorly understood. To address this need, an effective and relevant in vitro model for the study of prostate cancer bone metastases would be useful. Therefore, a 3D in vitro tissue system was established using prostate cancer cells (PC3), suitable culture conditions and a 3D silk scaffold biomaterial to provide mechanically robust and slow degrading matrices to… CONTINUE READING

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