Development of an in vitro model to investigate joint ochronosis in alkaptonuria.

@article{Tinti2011DevelopmentOA,
  title={Development of an in vitro model to investigate joint ochronosis in alkaptonuria.},
  author={Laura Tinti and Adam M Taylor and Annalisa Santucci and Brenda Wlodarski and Peter J. M. Wilson and Jonathan C. Jarvis and W. D. Fraser and John S. Davidson and Lakshminarayan R. Ranganath and James P. Gallagher},
  journal={Rheumatology},
  year={2011},
  volume={50 2},
  pages={
          271-7
        }
}
OBJECTIVES Alkaptonuria (AKU) is a genetic disorder caused by lack of the enzyme responsible for breaking down homogentisic acid (HGA), an intermediate in tyrosine metabolism. HGA is deposited as a polymer, termed ochronotic pigment, in collagenous tissues. Pigmentation is progressive over many years, leading to CTDs including severe arthropathies. To investigate the mechanism of pigmentation and to determine how it leads to arthropathy, we aimed to develop an in vitro model of ochronosis… CONTINUE READING

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