Development of an in vitro model for investigating the formation of the nuclear Ah receptor complex in mouse Hepa 1c1c7 cells.

@article{Wang1994DevelopmentOA,
  title={Development of an in vitro model for investigating the formation of the nuclear Ah receptor complex in mouse Hepa 1c1c7 cells.},
  author={Xiaoyan Aria Wang and Stephen Safe},
  journal={Archives of biochemistry and biophysics},
  year={1994},
  volume={315 2},
  pages={285-92}
}
An in vitro assay for investigating factors which modulate formation of the nuclear aryl hydrocarbon (Ah) receptor complex was developed using 9S cytosolic Ah receptor isolated from wild-type Hepa 1c1c7 cells treated with 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin (TCDD) at 4 degrees C and nuclei from Ah-responsive and -nonresponsive wild-type and mutant Hepa 1c1c7 cells. Incubation of the radiolabeled ([3H]TCDD) 9S cytosolic Ah receptor with nuclei from untreated wild-type Ah-responsive mouse… CONTINUE READING

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