Development of an experimental murine pulmonary metastasis model incorporating a viral encoded tumor specific antigen.

@article{Watts1997DevelopmentOA,
  title={Development of an experimental murine pulmonary metastasis model incorporating a viral encoded tumor specific antigen.},
  author={A. M. Watts and Michael H. Shearer and Harvey I. Pass and Ronald C. Kennedy},
  journal={Journal of virological methods},
  year={1997},
  volume={69 1-2},
  pages={93-102}
}
A SV40 murine tumor model was developed and characterized involving intravenous inoculation of BALB/c mice with syngeneic SV40-transformed kidney fibroblasts (mKSA cells). Following intravenous inoculation with mKSA cells, viable tumor cells were recovered from primary organ cell culture of the brain, spleen, lungs, and kidneys of tumor bearing mice. The presence of mKSA tumor cells in these tissues was confirmed by morphological identification and by immunofluorescence directed to SV40 large… CONTINUE READING