Development of an efficient transdermal delivery system of small interfering RNA using functional peptides, Tat and AT-1002.

@article{Uchida2011DevelopmentOA,
  title={Development of an efficient transdermal delivery system of small interfering RNA using functional peptides, Tat and AT-1002.},
  author={Tamae Uchida and Takanori Kanazawa and Yuuki Takashima and Hiroaki Okada},
  journal={Chemical & pharmaceutical bulletin},
  year={2011},
  volume={59 2},
  pages={196-201}
}
Topical use of small interfering RNA (siRNA) as a therapeutic nucleic acid is increasingly studied for the treatment of skin diseases and for the improvement of skin properties. However, naked siRNA transdermal delivery is limited by its low stability in the body and low permeability into target cells. This is due to various skin barriers such as the stratum corneum that has multiple lipid bilayers and epidermal layers that have tight junctions. In this study, we investigate non-invasive… CONTINUE READING

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