Development of an attenuated strain of chikungunya virus for use in vaccine production.

Abstract

An attenuated chikungunya (CHIK) virus clone was developed for production of a live vaccine for human use. CHIK strain 15561 was subjected to 18 plaque-to-plaque passages in MRC-5 cultures before CHIK 181/clone 25 was selected as vaccine seed based on homogeneous small plaque size, suckling mouse avirulence, reduced monkey viraemia and genetic stability… (More)

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Cite this paper

@article{Levitt1986DevelopmentOA, title={Development of an attenuated strain of chikungunya virus for use in vaccine production.}, author={Nathan Levitt and H H Ramsburg and Stephanie E Hasty and Patricia M Repik and Francesca Cole and Henry Lupton}, journal={Vaccine}, year={1986}, volume={4 3}, pages={157-62} }