Development of an asymmetric trimethylenemethane cycloaddition reaction: application in the enantioselective synthesis of highly substituted carbocycles.

@article{Trost2011DevelopmentOA,
  title={Development of an asymmetric trimethylenemethane cycloaddition reaction: application in the enantioselective synthesis of highly substituted carbocycles.},
  author={Barry M Trost and Steven M. Silverman and James P. Stambuli},
  journal={Journal of the American Chemical Society},
  year={2011},
  volume={133 48},
  pages={19483-97}
}
A protocol for the enantioselective [3+2] cycloaddition of trimethylenemethane (TMM) with electron-deficient olefins has been developed. The synthesis of novel phosphoramidite ligands was critical in this effort, and the preparation and reactivity of these ligands is detailed. The evolution of the ligand design, commencing with acyclic amine-derived… CONTINUE READING