Development of an animal model for neuroleptic malignant syndrome: heat-exposed rabbits with haloperidol and atropine administration exhibit increased muscle activity, hyperthermia, and high serum creatine phosphokinase level.

@article{Tanii1996DevelopmentOA,
  title={Development of an animal model for neuroleptic malignant syndrome: heat-exposed rabbits with haloperidol and atropine administration exhibit increased muscle activity, hyperthermia, and high serum creatine phosphokinase level.},
  author={Hideji Tanii and Nobuaki Taniguchi and H Niigawa and Takayoshi Hosono and Yasumitsu Ikura and Sachiyo Sakamoto and Takashi Kudo and Tsunehiko Nishimura and Masatoshi Takeda},
  journal={Brain research},
  year={1996},
  volume={743 1-2},
  pages={263-70}
}
The neuroleptic malignant syndrome (NMS) is a life-threatening complication of neuroleptic treatment. To elucidate the pathogenesis of NMS, an animal model has been developed. Experimental rabbits treated with haloperidol (1 mg/kg) by intramuscular injection, were studied for the diagnostic symptoms of increased muscle rigidity, elevated body temperature, and high serum creatine phosphokinase (CPK) level. Administration of haloperiodol (1 mg/kg) and atropine (0.4 mg/kg), and exposure to high… CONTINUE READING