Development of an Experimental Animal Model for Lower Back Pain by Percutaneous Injury-Induced Lumbar Facet Joint Osteoarthritis.

@article{Kim2015DevelopmentOA,
  title={Development of an Experimental Animal Model for Lower Back Pain by Percutaneous Injury-Induced Lumbar Facet Joint Osteoarthritis.},
  author={Jae-Sung Kim and Kasra Ahmadinia and X Allen Li and John L. Hamilton and Steven Andrews and Chris A Haralampus and Guozhi Xiao and Hong-Moon Sohn and Jae-Won You and Yo-Seob Seo and Gary S Stein and Andre J van Wijnen and Su-Gwan Kim and Hee-Jeong Im},
  journal={Journal of cellular physiology},
  year={2015},
  volume={230 11},
  pages={2837-47}
}
We report generation and characterization of pain-related behavior in a minimally invasive facet joint degeneration (FJD) animal model in rats. FJD was produced by a non-open percutaneous puncture-induced injury on the right lumbar FJs at three consecutive levels. Pressure hyperalgesia in the lower back was assessed by measuring the vocalization response to pressure from a force transducer. After hyperalgesia was established, pathological changes in lumbar FJs and alterations of intervertebral… CONTINUE READING

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