Development of an ER action indicator mouse for the study of estrogens, selective ER modulators (SERMs), and Xenobiotics.

@article{Nagel2001DevelopmentOA,
  title={Development of an ER action indicator mouse for the study of estrogens, selective ER modulators (SERMs), and Xenobiotics.},
  author={Susan C. Nagel and J L Hagelbarger and Donald P McDonnell},
  journal={Endocrinology},
  year={2001},
  volume={142 11},
  pages={4721-8}
}
We have developed a transgenic mouse that functions as a reporter of ER activity, termed ER action indicator (ERIN), by incorporating a transgene with an estrogen-responsive promoter (three copies of the vitellogenin estrogen response element with a minimal thymidine kinase promoter) linked to the reporter gene beta-galactosidase. Evaluation of ER activity in female ERIN mice demonstrated estrogen-inducible expression of the reporter gene in the uterus, pituitary, and hypothalamus; established… CONTINUE READING
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