Development of an Acute Model for the Study of Chloromethanediphosphonate Nephrotoxicity

@article{Alden1989DevelopmentOA,
  title={Development of an Acute Model for the Study of Chloromethanediphosphonate Nephrotoxicity},
  author={C. Alden and R. Parker and D. Eastman},
  journal={Toxicologic Pathology},
  year={1989},
  volume={17},
  pages={27 - 32}
}
  • C. Alden, R. Parker, D. Eastman
  • Published 1989
  • Medicine
  • Toxicologic Pathology
  • Chloromethanediphosphonate (Cl2MDP), a cation chelator, is used as a therapeutic for hypercalcemia of malignancy. Cl2MDP exhibits nephrotoxic potential. Thus, a useful model has been developed to study the mechanism of injury. Intraperitoneal administration of highly exaggerated dosages, specifically 200 mg/kg b.i.d., resulted in a consistent mild to moderate extent of kidney damage after the third day of treatment in rats. Proteinuria and lowered serum phosphorus levels occur prior to onset of… CONTINUE READING
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