Development of acute dystonia and tardive dyskinesia in cebus monkeys.

  title={Development of acute dystonia and tardive dyskinesia in cebus monkeys.},
  author={Sven B{\'a}r{\'a}ny and A Ingvast and Lars M. Gunne},
  journal={Research communications in chemical pathology and pharmacology},
  volume={25 2},
In 4 out of 11 cebus apella monkeys given haloperidol (0.05 - 1.0 mg/kg/d) orally for up to 35 months signs of tardive dyskinesia (TD) hav developed: 1) One monkey developed barely noticeable TD after 4 months, but showed marked and increasing symtpoms of both generalized choreic and buccolingual TD after 8 months. This animal died 3 months after discontinuation of haloperidol. At that time the signs of TD were still prominent. 2) In one monkey bucco-lingual TD appeared after 3 months and was… CONTINUE READING
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