Development of acute burn shock in unresuscitated guinea pigs.

@article{Adams1981DevelopmentOA,
  title={Development of acute burn shock in unresuscitated guinea pigs.},
  author={H Richard Adams and Christopher Robert Baxter and Janet L. Parker and R S Senning},
  journal={Circulatory shock},
  year={1981},
  volume={8 6},
  pages={613-25}
}
Conscious guinea pigs were used to study the development of burn shock as a function of the size of thermal injury to the body surface. Scale burns equivalent to 0 (control, n = 18), 15.7 +/- 0.8% (n = 11), 24.6 +/- 0.5% (n = 10), and 43.4 +/- 1.5% (n = 10) of total body surface area were obtained by use of a template device, while the animals were deeply anesthetized with methoxyflurane. Circulatory function was assessed without further anesthetic restraint before and at 1, 2, 4, 6, 8, and 24… CONTINUE READING

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