Development of a validated LC-MS/MS method for determination of doxofylline on rat dried blood spots and urine: application to pharmacokinetics.

Abstract

A rapid and highly sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) method for determination of doxofylline on rat dried blood spots and urine was developed and validated. The chromatographic separation was achieved on a reverse phase C18 column (250 mm × 4.6 mm, 5 μm), using 20 mM ammonium acetate (pH adjusted to 3.5 with… (More)
DOI: 10.1016/j.jpba.2013.02.017

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@article{Rao2013DevelopmentOA, title={Development of a validated LC-MS/MS method for determination of doxofylline on rat dried blood spots and urine: application to pharmacokinetics.}, author={R C Nageswara Rao and K. Guru Prasad and Ch Gangu Naidu and Shaik Saida and Sachin B Agwane}, journal={Journal of pharmaceutical and biomedical analysis}, year={2013}, volume={78-79}, pages={211-6} }