Development of a universal nucleobase and modified nucleobases for expanding the genetic code.

Abstract

This unit presents protocols for the synthesis and characterization of nucleosides with unnatural bases in order to develop bases for the expansion of the genetic alphabet or for nonselective pairing opposite natural bases. Protocols describe the design, synthesis, and characterization of unnatural base pairs involving 1-beta-D-2-deoxyribosyl-N- and -C… (More)
DOI: 10.1002/0471142700.nc0105s10

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