Development of a tripartite vector system for live oral immunization using a gram-negative probiotic carrier.

@article{Buddenborg2008DevelopmentOA,
  title={Development of a tripartite vector system for live oral immunization using a gram-negative probiotic carrier.},
  author={Christian Buddenborg and Damini Daudel and Shanti Liebrecht and Lilo Greune and Verena Humberg and M Alexander Schmidt},
  journal={International journal of medical microbiology : IJMM},
  year={2008},
  volume={298 1-2},
  pages={105-14}
}
The mucosa represents the primary target site and thus the first barrier for most microbial pathogens. Nevertheless, nearly all present-day vaccines are applied by an invasive route, target the systemic immune system, and do not confer efficient mucosal protection. Currently, mucosal immunity can only be achieved by the delivery of antigens via the mucosal route. Therefore, multiple efforts are under way to develop mucosal vaccines and particularly live oral vaccines as these would confer… CONTINUE READING
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