Development of a three-dimensional physiological model of the internal anal sphincter bioengineered in vitro from isolated smooth muscle cells.

@article{Hecker2005DevelopmentOA,
  title={Development of a three-dimensional physiological model of the internal anal sphincter bioengineered in vitro from isolated smooth muscle cells.},
  author={Louise Hecker and Keith Baar and Robert G. Dennis and Khalil N. Bitar},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2005},
  volume={289 2},
  pages={G188-96}
}
Fecal incontinence affects people of all ages and social backgrounds and can have devastating psychological and economic consequences. This disorder is largely attributed to decreased mechanical efficiency of the internal anal sphincter (IAS), yet little is known about the pathophysiological mechanisms responsible for the malfunction of sphincteric smooth… CONTINUE READING