Development of a surrogate matrix for cerebral spinal fluid for liquid chromatography/mass spectrometry based analytical methods.

@article{Hooshfar2016DevelopmentOA,
  title={Development of a surrogate matrix for cerebral spinal fluid for liquid chromatography/mass spectrometry based analytical methods.},
  author={Shirin Hooshfar and Babak Basiri and Michael G Bartlett},
  journal={Rapid communications in mass spectrometry : RCM},
  year={2016},
  volume={30 7},
  pages={854-8}
}
RATIONALE In recent years, several liquid chromatography/tandem mass spectrometry (LC/MS/MS) methods have been reported for the quantitative determination of drugs and metabolites in cerebral spinal fluid (CSF). Artificial CSF (aCSF) is often used as a surrogate for preparing calibration curves and quality control samples in these methods. However, aCSF does not accurately represent the composition of real CSF because it is missing all of the proteins and lipids, which may alter the… CONTINUE READING