Development of a structural model for the cytoplasmic domain of an integrin.

@article{Haas1997DevelopmentOA,
  title={Development of a structural model for the cytoplasmic domain of an integrin.},
  author={Thomas A. Haas and Edward F Plow},
  journal={Protein engineering},
  year={1997},
  volume={10 12},
  pages={1395-405}
}
The cytoplasmic tails of integrin heterodimers play central roles in controlling the activation states of integrins and in transmitting intracellular signals. Despite their short length, no structure of any integrin cytoplasmic domain has been determined. Therefore, molecular models for the cytoplasmic domain of alpha(IIb)beta3, the major platelet integrin, were generated, including models for the individual cytoplasmic tails, the binary alphaIIb-calcium complex, and the ternary alphaIIb-beta3… CONTINUE READING