Development of a statistically robust quantification method for microorganisms in mixtures using oligonucleotide microarrays.

@article{Pozhitkov2007DevelopmentOA,
  title={Development of a statistically robust quantification method for microorganisms in mixtures using oligonucleotide microarrays.},
  author={Alexander E. Pozhitkov and Kyle Bailey and Peter A. Noble},
  journal={Journal of microbiological methods},
  year={2007},
  volume={70 2},
  pages={292-300}
}
High-density oligonucleotide arrays can be extremely useful for identifying and quantifying specific targets (i.e., ribosomal RNA of microorganisms) in mixtures. However, current array identification schemes are severely compromised by nonspecific hybridization, resulting in numerous false-positive and false-negative calls, they lack an adequate internal… CONTINUE READING