Development of a small-scale bioreactor for drug metabolism studies maintaining hepatospecific functions.

@article{Bader1998DevelopmentOA,
  title={Development of a small-scale bioreactor for drug metabolism studies maintaining hepatospecific functions.},
  author={Augustinus Bader and Norbert Fr{\"u}hauf and Karl Zech and Axel Haverich and J T Borlak},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1998},
  volume={28 9},
  pages={815-25}
}
1. The aim of the study was the development of a small-scale liver cell bioreactor maintaining tissue monoxygenase activity and hepatospecific activities over at least 2 weeks. 2. For characterization the antihypertensive drug urapidil was used as a model compound to study maintenance of metabolic activity. Tissue-specific parameters assessed included urea and albumin secretion as well as cellular integrity. The problem of the use of serum in bioreactor cultures is addressed. 3. Bioreactor runs… CONTINUE READING