Development of a size-restricted pIX-deleted helper virus for amplification of helper-dependent adenovirus vectors

Abstract

Helper-dependent adenovirus vectors (hdAd), which are deleted of all viral protein-coding sequences, can mediate long-term expression of a therapeutic transgene and lead to life-long, phenotypic correction in animal models of genetic disease. Here, we describe a new system for the generation of hdAd, which utilizes the DNA size restrictions imposed on an Ad… (More)
DOI: 10.1038/sj.gt.3302107

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