Development of a simple homogeneous assay to screen for inhibitors of N-acetylglucosamine-6-sulfotransferases.

@article{Togame2003DevelopmentOA,
  title={Development of a simple homogeneous assay to screen for inhibitors of N-acetylglucosamine-6-sulfotransferases.},
  author={H. Togame and M. Shimazaki and A. Yamato and S. Watanabe and K. Saito and P. Reinemer},
  journal={Analytical biochemistry},
  year={2003},
  volume={315 1},
  pages={
          67-76
        }
}
  • H. Togame, M. Shimazaki, +3 authors P. Reinemer
  • Published 2003
  • Chemistry, Medicine
  • Analytical biochemistry
  • L-selectin, a leukocyte adhesion molecule, plays a central role in lymphocyte homing to secondary lymphoid tissue and to certain sites of inflammation. Carbohydrate sulfation was implicated in this process, when it was demonstrated that carbohydrate sulfotransferase-mediated sulfation of N-acetylglucosamine (GlcNAc) within sialyl Lewis X of cognate endothelial ligands for L-selectin was an essential modification for L-selectin binding. The recently identified GlcNAc-6-sulfotransferases… CONTINUE READING

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