Development of a series of novel carbon-11 labeled PDE10A inhibitors.

  title={Development of a series of novel carbon-11 labeled PDE10A inhibitors.},
  author={Vladimir Stepanov and Shotaro Miura and Akihiro Takano and Nahid Amini and Ryuji Nakao and Tomoaki Hasui and Kosuke Nakashima and Takahiko Taniguchi and Haruhide Kimura and Takanobu Kuroita and Christer Halldin},
  journal={Journal of labelled compounds & radiopharmaceuticals},
  volume={58 5},
Phosphodiesterase 10A (PDE10A) is a member of the PDE family of enzymes that degrades cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Our aim was to label a series of structurally related PDE10A inhibitors with carbon-11 and evaluate them as potential positron emission tomography (PET) radioligands for PDE10A using nonhuman primates. The series consisted of seven compounds based on the 3-(1H-pyrazol-5-yl)pyridazin-4(1H)-one backbone. These compounds were… CONTINUE READING