Development of a sensitive assay for the measurement of antibodies against heat shock protein binding protein 1 (HspBP1): increased levels of anti-HspBP1 IgG are prevalent in HIV infected subjects.

@article{Papp2005DevelopmentOA,
  title={Development of a sensitive assay for the measurement of antibodies against heat shock protein binding protein 1 (HspBP1): increased levels of anti-HspBP1 IgG are prevalent in HIV infected subjects.},
  author={Di{\'a}na Papp and Zolt{\'a}n Proh{\'a}szka and Judit Kocsis and George F{\"u}st and D{\'e}nes B{\'a}nhegyi and Deborah A. Raynes and Vince Guerriero},
  journal={Journal of medical virology},
  year={2005},
  volume={76 4},
  pages={
          464-9
        }
}
The 70 kDa heat shock protein (Hsp70) is generally considered to be an intracellular protein, however, there is evidence that Hsp70 can be found in the extracellular environment. Hsp70 and antibodies against Hsp70 have been reported in human serum. Recent evidence has shown that Hsp70 antibodies are elevated in HIV infected individuals. This study reports on the antibody levels against a co-chaperone, HspBP1, that regulates Hsp70 activity. We have developed a solid-phase enzyme linked assay for… CONTINUE READING

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