Development of a semimechanistic model to describe the pharmacokinetics of gentamicin in patients receiving hemodialysis.

@article{Dang2006DevelopmentOA,
  title={Development of a semimechanistic model to describe the pharmacokinetics of gentamicin in patients receiving hemodialysis.},
  author={Lily Dang and Stephen Duffull},
  journal={Journal of clinical pharmacology},
  year={2006},
  volume={46 6},
  pages={662-73}
}
The aim of this study was to ascertain the most suitable dosing schedule for gentamicin in patients receiving hemodialysis. We developed a model to describe the concentration-time course of gentamicin in patients receiving hemodialysis. Using the model, an optimal dosing schedule was evaluated. Various dosing regimens were compared in their ability to achieve maximum concentration (C(max), > or = 8 mg/L) and area under the concentration time-curve (AUC > or = 70 mg x h/L and < or = 120 mg x h/L… CONTINUE READING

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