Development of a rubella virus vaccine expression vector: use of a picornavirus internal ribosome entry site increases stability of expression.

@article{Pugachev2000DevelopmentOA,
  title={Development of a rubella virus vaccine expression vector: use of a picornavirus internal ribosome entry site increases stability of expression.},
  author={Konstantin V. Pugachev and W P Tzeng and Teryl K. Frey},
  journal={Journal of virology},
  year={2000},
  volume={74 22},
  pages={10811-5}
}
Rubella virus (RUB) is a small plus-strand RNA virus classified in the Rubivirus genus of the family Togaviridae. Live, attenuated RUB vaccines have been successfully used in vaccination programs for over 25 years, making RUB an attractive vaccine vector. In this study, such a vector was constructed using a recently developed RUB infectious cDNA clone (Robo). Using a standard strategy employed to produce expression and vaccine vectors with other togaviruses, the subgenomic promoter was… CONTINUE READING
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